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Diagnostic instrument

maharastra 400086

91 22 2511 24 24

91 22 25157265

Email Address:
[email protected]


method (UBT)
is based on the fact that the bacteria H. pylori produces an enzyme, urease, which
catalyzes the hydrolysis of the urea molecule into ammonium and carbon dioxide.
H. pylori requires the alkaline ammonium in order to establish an optimal local
mucosal environment within the acidic environment of the stomach. The
urea compound is an endogenous substance that contains one
carbon atom, normally 12C, which can be replaced by its
isotope 14C or 13C. Heliprobe" uses the isotope 14C which
has very low ▀-radioactive emission. The radioactive dose
used for a Heliprobe" test is 1 ╝Curie, which is significantly
less than the radioactive dose given at a normal X-ray
examination of the stomach, and equal to a few glasses of orange juice.
A Helicap is ingested with 50 ml of water. If an infection with H. pylori is present in
the stomach, the "living" bacteria produces the enzyme urease that metabolizes the
14C-urea into ammonium and carbon dioxide containing the 14C-labelled atoms. The
carbon dioxide will be assimilated through the mucosa into the blood stream and
transported to the lungs where it is exhaled. By collecting the exhaled carbon dioxide
in the BreathCard", the amount of 14CO2 produced in the stomach can be measured
with the Heliprobe" instrument. If the patient is not infected, no metabolization of
urea will occur and therefore no 14CO2 can be detected with the Heliprobe" system.
In this case the unmetabolized 14C urea will pass along the digestive canal to be
excreted in the urine. If the Heliprobe" system detects 14CO2, this is diagnostic
evidence of an ongoing infection with living H. pylori. Heliprobe" is developed for
primary diagnosis of H. pylori, as well as for follow-up after eradication treatment.
Since Barry Marshall described the
Helicobacter pylori (H.pylori) and its role in different gastrointestinal diseases, an
intense research effort has developed different diagnostic methods. The only noninvasive
test method that can be clinically used as a diagnostic tool for on-going
infection with H. pylori and post-eradication follow-up is the urea breath test.
Different serological tests are available, but they cannot determine the actual status
of the infection and can therefore only be used for screening tests. With the
Heliprobe", a cost-effective test is available, easy to use in the doctor's office .

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